Cagrilintide
Long-acting amylin analog for appetite suppression and weight management.
1 mg/week
Key Benefits
central amylin receptor activation reduces food intake
~7 days enables once-weekly dosing
CagriSema combination shows 25% weight loss
reduces cardiovascular risk markers
Recommended Injection Sites
Optimal injection locations for Cagrilintide based on its route (Subcutaneous injection) and pharmacokinetic profile.
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Preferred for weekly injections.
Good alternative.
Use if other sites unavailable.
Rotate weekly injection sites.
- IV administration
- Intramuscular injection
Active Signaling Pathway
Recommended Stacks
Cagrilintide is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.
Metabolic Reset Protocol
Next-generation GLP-1 + amylin combination for advanced weight management research.
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 5mg vial — and when to plan your next order.
Actual duration may vary based on your specific protocol. Always consult your research guidelines for precise dosing schedules.
Scientific Background
Mechanism of Action
Cagrilintide binds amylin receptors (AMY1–3) in the area postrema and hypothalamus, reducing food intake via central satiety signaling. Its fatty acid modification enables albumin binding, extending half-life to ~7 days. Combined with GLP-1 agonists, it provides complementary and synergistic appetite suppression.
Clinical Context
Cagrilintide is currently in Phase 3 trials as part of the CagriSema combination. It represents the next generation of weight management research beyond GLP-1 monotherapy.
Research Highlights
- Phase 2 trials showed 15.6% weight loss as monotherapy over 26 weeks
- CagriSema combination demonstrated up to 25% weight reduction — exceeding either agent alone
- Half-life of ~7 days enables once-weekly dosing
- Demonstrated improvements in cardiometabolic risk markers in obese subjects
Storage & Reconstitution
Store at -20°C. Reconstitute with 1 mL bacteriostatic water → 5 mg/mL. Stable 28 days at 2–8°C. Protect from light.
Titrate dose over 16 weeks. Can be combined with semaglutide for synergistic effect.