Kisspeptin-10
Hypothalamic neuropeptide regulating GnRH and reproductive hormone axis.
50 mcg/day
Key Benefits
directly activates hypothalamic GnRH neurons for hormonal cascade
drives pituitary gonadotropin secretion for testosterone and fertility support
master regulator of reproductive endocrine function
used in clinical studies for hypogonadism and fertility
Recommended Injection Sites
Optimal injection locations for Kisspeptin-10 based on its route (Subcutaneous injection) and pharmacokinetic profile.
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Preferred SubQ site.
Good alternative.
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- IV administration without clinical supervision
Active Signaling Pathway
Recommended Stacks
Kisspeptin-10 is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.
Hormonal Vitality Stack
HPG axis activation and melanocortin optimization for vitality and libido research.
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 5mg vial — and when to plan your next order.
Actual duration may vary based on your specific protocol. Always consult your research guidelines for precise dosing schedules.
Scientific Background
Mechanism of Action
Kisspeptin-10 binds the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release. This activates the pituitary to secrete LH and FSH, which in turn stimulate gonadal steroidogenesis. It is the master regulator of the reproductive endocrine axis.
Clinical Context
Kisspeptin is now recognized as the primary upstream regulator of the HPG axis. Clinical trials are ongoing for its use in fertility treatment and hormonal disorders.
Research Highlights
- Single IV dose shown to increase LH by 10–20× in healthy volunteers
- Used in clinical research to diagnose and treat hypogonadotropic hypogonadism
- Demonstrated role in puberty onset and fertility regulation
- Research shows potential for testosterone optimization in males with secondary hypogonadism
Storage & Reconstitution
Pulsatile dosing mimics physiological GnRH release. Typical research cycle: 4–8 weeks.