TB-500 5mg
Thymosin Beta-4 — systemic tissue repair and anti-inflammatory peptide for accelerated recovery.
2 mg twice weekly (loading)
Key Benefits
travels via bloodstream to reach injury sites throughout the entire body
sequesters G-actin to promote cell movement and proliferation at repair sites
downregulates IL-6 and TNF-α to reduce chronic inflammation
stimulates VEGF pathway to improve blood supply to healing tissue
Recommended Injection Sites
Optimal injection locations for TB-500 5mg based on its route (Subcutaneous or intramuscular) and pharmacokinetic profile.
Tap a glowing zone on the body map to highlight the matching site card — or tap a card to activate the zone.
Tap a zone to inject
Standard SubQ site. Distributes systemically regardless of injection location.
Convenient self-injection site with good absorption.
Good alternative. Use 5/16" needle.
Rotate injection sites. TB-500 distributes systemically — injection location is flexible.
- IV administration
- Direct injection into joint space
Active Signaling Pathway
Recommended Stacks
TB-500 5mg is a key compound in these curated research stacks. Pair it with synergistic peptides for enhanced outcomes.
Recovery Accelerator
BPC-157 + TB-500 — the gold-standard dual-peptide protocol for connective tissue, muscle, and systemic repair.
How long will one vial last?
Based on standard research protocols, here's exactly what to expect from a single 5mg vial — and when to plan your next order.
Actual duration may vary based on your specific protocol. Always consult your research guidelines for precise dosing schedules.
Scientific Background
Mechanism of Action
TB-500 works primarily by sequestering G-actin (monomeric actin), which promotes cell migration and proliferation at injury sites. It upregulates actin-binding proteins, stimulates angiogenesis via VEGF pathway activation, reduces inflammation by downregulating inflammatory cytokines (IL-6, TNF-α), and promotes differentiation of stem cells into repair-competent cells. Its systemic distribution via blood allows it to reach distant injury sites.
Clinical Context
TB-500 is widely used in research protocols for musculoskeletal injuries, particularly when the injury is difficult to inject near (e.g., spine, deep tissue). Its systemic distribution makes it complementary to BPC-157, which has more localized effects. The combination of BPC-157 + TB-500 (the Wolverine Stack) is one of the most popular recovery protocols.
Research Highlights
- Demonstrated systemic tissue repair — distributes via bloodstream to reach distant injury sites
- Shown to reduce cardiac fibrosis and promote heart muscle repair in myocardial infarction models
- Anti-inflammatory effects documented — reduces IL-6 and TNF-α at injury sites
- Promotes hair follicle stem cell activation — studied for hair regrowth applications
Storage & Reconstitution
Loading phase: 2–2.5 mg twice weekly × 4–6 weeks. Maintenance: 2 mg once weekly. Can be injected anywhere — distributes systemically.